Rupert Cox from the Somerset Chamber of Commerce said at the peak of engineering, 5,500 people will be needed to work on the Hinkley Point C site.
He added, "that's nearly as many people that are on job seekers allowance at the moment in Somerset".
Campaign group Stop Hinkley has staged a protest outside EDF offices in Bridgwater against the building of a new nuclear power station at Hinkley Point.
These time-lapse pictures from the protest group show campaigners putting up banners outside the office.
The government has given the go ahead to build Britain's first new nuclear power station in a decade at Hinkley Point near Bridgwater.
The announcement will see an investment of £16 billion, and the creation of 25,000 jobs.
As part of the deal, the government has agreed a so-called strike price with EDF for the amount it gets per megawatt hour of electricity.
The figure settled on today is £92.50 which is more than double the current market rate, the Prime Minister said it was a good deal.
The Prime Minister and the Energy Secretary have been taken on a tour around the Hinkley site where Britain's newest nuclear power plant will be built.
A video produced by EDF energy showing a CGI fly-through over the new Hinkley Point nuclear station allows people to go on a "virtual visit" of the site.
Today the Prime Minister confirmed that Britain's first new nuclear reactor for a generation will go ahead.
Hinkley C will become the single largest construction project in the UK, it will take 10 years to deliver and will cost billions.
Energy Secretary Ed Davey told a news conference in London it was a "historic" day.
He said the UK was facing a "looming energy crisis" in the next decade thanks to years of neglect and under-investment.
Much of coal and nuclear-generated energy will stop in the coming years.
"We have known for years this is coming, but no-one was willing to take tough decisions."
Mr Davey stressed the project included plans to cover the costs of de-commissioning, with the operators required to pay into a fund from day one.
Greenpeace UK director John Sauven said:
Hinkley C fails every test - economic, consumer, and environmental.
It will lock a generation of consumers into higher energy bills via a strike price that's nearly double the current price of electricity, and it will distort energy policy by displacing newer, cleaner, technologies that are dropping dramatically in price.
With companies like Dong Energy now saying the price of offshore wind will drop so much it will be on par with nuclear by the 2020s, there is little rationale for allowing Hinkley C to proceed.
Giving it the green light when there is no credible plan for dealing with the waste is also unacceptable. David Cameron has said himself that, until the waste issue is sorted, no new investment is possible.
This is yet another Government U-turn which is creating uncertainty for investment in both energy efficiency and renewable energy, which, despite recent headlines, remain the best long-term solution for the consumer, energy security and tackling climate change.
John Cridland, CBI director-general, welcomed the Hinkley nuclear deal as a "fundamental feature of our future energy landscape."
This is a landmark deal which will help us meet our future energy challenges, while boosting jobs and growth.
New nuclear plants must be a fundamental feature of our future energy landscape, and Hinkley Point C is the starter gun to securing the investment we need.
Amid understandable public concern about rising bills, it's important to remember this investment will help mitigate the impact of increasing costs.
The fact is whatever we do, energy prices are going to have to go up to replace ageing infrastructure and meet climate change targets - unless we build new nuclear as part of a diverse energy mix.
"If we're going to have cleaner energy, a more secure energy, it's not going to come without paying a price," Jeremy Nicholson, of the Energy Intensive Users Group, told Daybreak.
"The one thing we are guaranteed out of this," he went on, " we're going to get secure energy, and that's worth something."
But the Green Party's Baroness Jones said the Hinkley deal was "a disastrous decision".
"At the moment we don't know what to do with the nuclear waste and that means we are giving our children and our grandchildren a huge cost to pick up cleaning up after we've finished with this energy."
"We calculate that by the end of the next decade - by 2030 - this will actually be saving consumers money," Energy Secretary Ed Davey told ITV Daybreak.
"We think the average consumer will be saving £77 a year on their bill thanks to the new nuclear programme that we're putting forward."