On ITV News West Country tonight at 6pm, we look at kidney donations from living donors. Most "live" donations are within families but there are a small number of altruistic donors who donate one of their kidneys to a person they don't know who's waiting on the transplant list.
Derriford Hospital in Plymouth is one of the pioneers of this type of transplant. Our Health Correspondent Jacquie Bird has been to watch one - watch her full report on tonight's programme.
ITV's From the Heart campaign - another special report tonight
All this week ITV is running a big campaign to raise awareness of organ donation. This week on ITV West Country we are hearing both from donor families and the patients whose lives have been transformed by organ donations, as well as the health professionals involved.
523 people in the South West are currently waiting for a transplant. On tonight's West Country News at 6, we visit the Transplant Duty Office in Bristol, whose job it is to make sure organs get to the right donor in time; hey have to move super fast at a moment's notice.
If you would like to find out more about ITV's From the Heart Campaign, there is lots of information here.