The westbound carriageway of the A38 has now re-opened after the old bridge at Merafield was demolished. Police say the eastbound carriageway is likely to stay closed until later this evening.
Diversion routes are said to be very congested. People heading from Cornwall are advised to use the A30.
Local users are advised to use the B3416.
Plymouth Argyle and Portsmouth fans travelling to today's League Two play off are facing delays as work on demolishing a bridge over runs. The old bridge at Merafield is being removed and replaced in a project costing £6 million.
Police say the A38 will re-open at 3pm. People are being advised to allow extra time to get to the game, which kicks off at 6pm.
Currently there are tailbacks to Smithaleigh and Manadon. There is a diversion through Plympton.
The project taking place this weekend has caused criticism from fans:
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Plymouth Argyle fans spent as long as 17 hours on the road without seeing a minute of football because of traffic "chaos."
The team were away to Morecambe on Good Friday, some 330 miles away.
The match was delayed by half an hour after fans travelling to the game ground to a halt in miles of tailbacks on the M6.
But many fans still missed the game as their coaches were turned back before reaching the Globe Arena.
The club described events as "heartbreaking" and said it could easily have been prevented. They've promised a thorough review.
It made no sense to schedule a fixture which involves a 660-mile round-trip for Plymouth-based Argyle supporters – and many of our fans will have had to travel even further – for one of the busiest weekends of the year.
Plymouth Argyle have signed high goal-scorer Jamille Matt on an emergency loan from Fleetwood Town.
The 6ft1 Jamaica-born forward has had his share of ups and downs, missing the whole 2014/2015 season with a serious injury, but he has since bounced back for Fleetwood, and will be with the Pilgrims for 28 days.
In tonight's football, it was honours even in the West Country derby at Huish Park, where Yeovil and Plymouth Argyle finished goal-less.
Elsewhere,Paul Tisdale's 500th game in charge of Exeter City has ended in disappointment. The Grecians lost 4-1 at home to Oxford. Alex Nicholls scored Exeter's consolation.
But it's back-to-back wins for Torquay United in the National League. The Gulls have beaten fellow strugglers Welling 2-0 at Plainmoor.
Nathan Smith and Iffy Allen with the goals in the second half.