In today's football, Yeovil Town travel to bottom-of-the-table Bolton. The Glovers are two places above their opponents in the Championship.
Gary Johnson's men are looking for their first win since the opening day of the season.
In League Two, Plymouth Argyle are also playing a team at the foot of the table. After two straight defeats, the Pilgrims will be hoping to get back to winning ways against Accrington Stanley at Home Park.
Exeter City travel to Fleetwood with new signing Danny Butterfield expected to make his debut. The 33-year-old defender was a free agent after leaving Carlisle.
Torquay United cross the Severn Bridge to play league new-boys Newport County. Striker Adebayo Azeez could be handed a debut after signing on a one-month youth loan from Charlton.
You can follow your team's progress by clicking on the links below for live text updates. All games kick-off at 3pm.
Exeter Chiefs entertain Leicester Tigers on Sunday at Sandy Park.
The reigning Premiership champions travel to Devon to face an Exeter side full of confidence after two successive victories.
20 year old Exeter Fly-half Henry Slade grew up watching many of the players he is likely to face if he comes off the replacements bench:
Plymouth Argyle are hoping to return to winning ways as they host Accrington Stanley at Home Park on Saturday.
Argyle had seen an improvement in their fortunes but back to back defeats halted that progress.
John Sheridan's side will seek a confidence boosting win ahead of the club's two biggest games of the season so far in the coming fortnight:
London Irish 23 Exeter 29
Exeter scored both of their tries in the final 20 minutes as they stormed home to victory over London Irish at the Madejski Stadium.
The visitors scored 15 unanswered points in the final quarter, including tries to Dean Mumm and Ben White, to secure a 29-23 win..
For the opening hour Irish were the better side, showing greater enterprise than a lethargic Exeter and with visitors' wing Tom James in the sin bin, the hosts appeared sure-fire winners.
Irish had already gone over through Nick Rouse and Marland Yarde in each half but they came to a standstill as 19 points from the boot of Gareth Steenson ensured Exeter sailed home.
In the Championship, Yeovil Town lost one nil at home against 2nd placed Queens Park Rangers. The only goal a second half penalty after Daniel Seabourne was penalised.
Exeter City lost two nil at home to Newport County. Connor Washington and Harry Worley got the goals for Newport
Plymouth Argyle went down 1-0 away to Scunthorpe who scored in the second half through Etienne Esajas after Argyle had had a goal by Reuben Reid disallowed.
Torquay won 4-2 two at home to Cheltenham. Callum Ball scored two for Torquay, The Gulls led 2-1 at half time. Karl Hawley and Jordan Chappell got the others after the break..
There is a full fixture list for our clubs this afternoon.
Yeovil take on Championship leaders QPR at Huish Park.
Exeter City are at home to league new boys Newport County
Plymouth Argyle are away to Scunthorpe
Torquay United are at home to Cheltenham
In last night's Championship games Cornish Pirates lost 27-20 at home to Leeds despite tries from Gavin Cattle and Craig Holland.
Plymouth Albion are top of the table despite being held to a draw 34-all by Moseley who came back from 31-13 down at half time to level the match.
This afternoon, Exeter Chiefs are away to London Irish in the Aviva Premiership
Exeter City were the region's only winners as sub John O'Flynn's injury time strike earned them three points at Northampton.Read the full story ›
The Championship season kicks-off tomorrow with a 'double header' fixture.
Plymouth Albion take on Jersey at 1.15pm. And that's followed by an all-West Country clash between the Cornish Pirates and Bristol.
Both games are taking place at Exeter's Sandy Park.
Exeter Chiefs secured their first win of the season after beating Wasps 30-26 at Sandy Park.
Tom James scored two tries for the Chiefs, with James Scaysbrook also crossing the line. 15 points came from the boot of Gareth Steenson.
For a full match report, visit the ITV Rugby website.