Passengers hoping to travel between Exeter St Davids and Taunton are experiencing delays of up to 70 minutes following an earlier closure.
The line between Exeter and Tiverton Parkway was shut for safety checks following a small landslip.
Delays are expected to clear by 3.30pm.
One lane is closed on the M5 Southbound between J26 (Wellington) and J27 (Tiverton).
It's due to an accident involving three cars earlier this evening. A woman has been taken to hospital with chest pains.
The condition of the other drivers is unknown at the moment. The other lanes are open and Police say there's no suggestion of any significant delays.
Two men have been seriously injured in a crash on the A361 at Tiverton. They have been taken to Derriford Hospital by air ambulance.
The crash involved three vehicles and happened on the southbound carriageway just past Bolham roundabout at 9.30am.
The A361 remains closed in both directions between Bolham roundabout in Tiverton to Stoneland Cross. Drivers are advised to avoid the area for the time being.
The A361 is closed in both directions due to a serious accident between A396 Bolham Road (Tiverton) and Rifton Lane (Templeton).
Traffic is being advised to find an alternate route.
The fine weather has been welcomed by events organisers up and down the region today.
There were excellent flying conditions in Devon where more than 15,000 people have been to the Tiverton Balloon Festival.
More than 40 balloons launched a mass ascent this morning.
Seth Conway reports:
More than 40 balloons are taking to the skies above Tiverton this weekend for the annual fiesta.Read the full story ›
A 20 year old man from Tiverton has been charged with attempted robbery and robbery after two incidents in the town last week.
A teenager was threatened with a knife at the entrance to People's Park in the town at just before 1pm on Wednesday. Money and a mobile phone were taken.
Ricky Noakes has appeared in court accused of the offences.
A 20 year old man has been arrested in connection with a robbery in Tiverton.
An 18 year old man was threatened with a knife just before 1pm on Wednesday at the entrance to People's Park.
Money and a mobile phone was stolen.
A local man has been arrested and is being questioned at Exeter Police Station.
The roof and first floor of a pub in Tiverton have been destroyed in a fire. It broke out at the Twyford Inn in Newport Street just after 10 am.
The ground floor is severely damaged by fire and water.
The fire was put out by crews who brought in an aerial ladder platform, ladders and a thermal image camera to check for hot spots.
The cause of the fire is still under investigation by the Fire Service and Police.
Western Power are also in attendance, isolating the electricity supply to the property.
Fire crews remain at the scene of a fire at the Twyford Inn in Tiverton. They were called to the scene in Newport Street just after 10 am today. At its height, more than 50 firefighters were working to bring it under control.
Their efforts have been caught on camera by photographer Michael Slater.