The A379 near Dawlish in South Devon was closed in both directions throughout the morning after an accident involving a motorbike.
The female rider, who was found a by a pedestrian, was taken to hospital with serious back injuries that are not thought to be life threatening.
Diversions were in force for several hours until the road was cleared.
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The bank holiday getaway is underway with twice the amount of traffic expected. Key routes across the west country are set to be hectic.
Blue skies and even more sunshine in the run up to the bank holiday weekend
The run-up to the bank holiday weekend probably has some of the best weather. Its fine with some blue skies or patchy cloud.