A serious crash, believed to be a collision between a tanker and a motorcyclist at the roundabout at Carkeel, has closed the A38 with motorists being diverted to the Torpoint Ferry instead.
The road is shut eastbound at Trerulefoot and westbound at Carkeel.
Police are advising motorists not to use St Germans as a cut through.
In addition, the Saltash Tunnel is closed westbound and traffic is being diverted through the town centre.
More top news
A vulnerable man has been repeatedly kicked and punched in a "vicious and unprovoked" street attack.
A dancing postman from Torquay has become an internet sensation after a video of him 'delivering a parcel' has received over a million views
We've been in awe with all the pictures you've been sending us. Here's as many as we can fit!