Plymouth Argyle have been knocked out of the League Cup on penalties, as all our sides crashed out.
After going two goals down to Leyton Orient, Reuben Reid scored twice to take the game into extra time. After falling behind again, Carl McHugh made it 3-3. But the League One side won 6-5 on sudden death spot-kicks.
Elsewhere, Exeter City lost 2-0 at home to Championship side Bournemouth.
Yeovil Town lost 2-1 at home to League One rivals Gillingham.
And Torquay United have won their first game in the Conference. They beat Welling 3-0 thanks to goals from Ryan Bowman, Courtney Cameron and Toby Ajala.
Plymouth Argyle and Yeovil Town both lose away from home but Torquay United continue to impress in the Conference with victory at Grimsby
There were wins for Yeovil Town, Plymouth Argyle and Torquay United. But Exeter City lost 2-1 at home to Mansfield.
Plymouth Argyle beat Southend in League Two, while Torquay United were the region's only other winners.