Harlequins v Wasps
Harlequins club captain Danny Care is not available for their season opener after suffering a back spasm on England duty. Former Australia captain James Horwill, Adam Jones and Mat Luamanu are set to make their debuts with other England players Joe Marler, Nick Easter and Mike Brown on the bench.
Sale Sharks have announced the signing of South Africa international prop Brian Mujati.
Mujati has agreed a two-year deal, and he will return to the Aviva Premiership following a long stint with Northampton before he joined French Top 14 club Racing 92.
Saracens created Aviva Premiership history at Twickenham as they beat Bath 28-16 to be crowned English champions for a second time in five years.
And in doing so, they became the first club since Premiership play-offs were introduced 12 years ago to lift silverware after finishing outside the top two following a 22-game regular season.
Bath will meet Saracens in next Saturday's Aviva Premiership final after three Matt Banahan tries helped send them to Twickenham for the first time since 2004.
Three first-half touchdowns - all converted by fly-half George Ford - gave Bath a commanding lead, with centre Kyle Eastmond also breaching Leicester's defence following an early Banahan double.
Saracens emerged triumphant from a heavyweight showdown at Franklin's Gardens to advance into next Saturday's Aviva Premiership final with a 29-24 victory over Northampton.
A thunderous first half at Franklin's Gardens finished 13-13 and inevitably the remainder of the play-off was reduced to a war of attrition between the rival forwards and goalkickers.
George North is unlikely to end his concussion lay-off to feature in Northampton's Aviva Premiership play-off semi-final against Saracens, according to Dorian West.