Australia wing James O'Connor has been ruled out of Friday's Rugby World Cup clash against the United States because of a hamstring strain.
The 21-year-old picked up the injury in the closing stages of last week's shock loss to Ireland, but an MRI scan on Tuesday revealed no serious damage.
It is hoped he will be available for the Wallabies' final group clash against Russia on 1 October.
O'Connor had only just returned to the starting line-up after being suspended for indiscipline.
With O'Connor unavailable, the door opens for Drew Mitchell to make his first Test start of the year.
Mitchell came into the World Cup under an injury cloud following an ankle injury in April but the talented winger has fully recovered and is expected to take O'Connor's place.
Australia are still unsure as to whether flanker David Pocock will be fit for the game against the United States.
The 23-year-old suffered a back injury in training and was a late withdrawal from the side that lost to Ireland on Saturday.
"At this point we're hopeful," said Australia assistant coach David Nucifora. "If you saw him on match day last week and see him now - it's a massive improvement.
"But if there is any doubt we won't risk any of our players making something that is relatively minor into something major."
Nucifora insisted there were no issues regarding the team's scrum, which was overpowered by Ireland at the weekend.
"Our scrum's gone well this year," added Nucifora. "We put the All Blacks and the Springboks under a lot of pressure and dominated them in recent matches, so it's not an issue for us.
"The Irish scrummed well the other night, we scrummed inconsistently. What we've got to fix is our consistency and our application to that.
"We don't have any issues with our scrum."
Meanwhile, winger Digby Ioane says he is targeting the World Cup quarter-finals for his comeback from a fractured thumb, suffered in the victory over Italy.
The 26-year-old still has his right hand in a cast but said he was pushing to be fit for the knockout rounds.
"Probably sometime this week I'll be taking off the cast and it all depends on my rehab but, fingers crossed, hopefully I'll make it for the quarters if we get there after last week's game," said Ioane, referring to the Wallabies shock loss to Ireland.
"I'm a big believer that things happen for a reason. I've been in this situation before so there's no need to be down about it. I've just got to get fit and come back stronger.
"It could have been worse. It could have been a shoulder or something. It gives me time to rest my shoulder. It would have been great to be playing with the boys. Watching the games is hard. I'm just looking forward to coming back."
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