Ireland coach Declan Kidney has made 10 changes, one positional, for Sunday's Rugby World Cup Pool C game with Russia in Rotorua.
Right winger Fergus McFadden is one of four Rugby World Cup debutants, with Keith Earls moving from the wing to outside centre, where he will play alongside Paddy Wallace, who will also be making his first appearance of the tournament.
Andrew Trimble starts on the left wing, with Ronan O'Gara and Isaac Boss forming the half-back partnership.
Hooker Sean Cronin replaces Rory Best for his tournament bow, alongside tighthead prop Tony Buckley, who makes his first start of the tournament.
In the back row, Donnacha Ryan replaces Stephen Ferris at blindside flanker.
Leo Cullen plays in the second row instead of Paul O'Connell, and will captain the side.
Injuries mean Russia have been forced to make nine changes, one of which is positional, from the side that scored three tries in the 53-17 loss to Italy in Nelson on Tuesday.
Scrum-half Alexander Yanyushkin, who impressed after coming on against Italy, starts in place of Vladislav Korshunov and also takes over as captain.
He will play alongside Konstantin Rachkov in the half-back.
Former Leinster player Vasily Artemyev keep his place in the backs but moves from right wing to full-back.
That allows highly-rated 20-year-old Siberian Denis Simplikevich to come into the side.
Another player making his first Rugby World Cup appearance is experienced inside centre Sergey Trishin, who was a late addition to the squad.
Up front prop Sergey Popov returns alongside Valeriy Tsnobiladze and Alexey Khrokin, who will become Russia's most capped forward as he makes his 75th appearance.
Denis Antonov and former Leinster Adam Byrnes form the second row partnership, with a back row of Victor Gresev, Artem Fatakhov and Andrey Garbuzov.
Ireland: Rob Kearney (UCD); Fergus McFadden (Old Belvedere), Keith Earls (Young Munster), Paddy Wallace (Ballymena), Andrew Trimble (Ballymena); Ronan O'Gara (Cork Constitution), Isaac Boss (Terenure College); Cian Healy (Clontarf), Sean Cronin (Leinster), Tony Buckley (Sale Sharks), Donncha O'Callaghan (Cork Constitution), Leo Cullen (Blackrock College, capt), Donnacha Ryan (Shannon), Sean O'Brien (Clontarf), Jamie Heaslip (Naas)
Replacements: Rory Best (Banbridge), Mike Ross (Clontarf), Dennis Leamy (Cork Constitution), Shane Jennings (St.Mary's College), Eoin Reddan (Lansdowne/Leinster), Jonathan Sexton (St. Mary's College), Geordan Murphy (Leicester Tigers)
Russia: Vasily Artemyev (Northampton Saints), Denis Simplikevich (Enisey-STM, Krasnoyarsk), Andrey Kuzin (VVA-Podmoskovye, Monino), Sergey Trishin (VVA-Podmoskovye, Monino), Vladimir Ostroushko (Enisey-STM, Krasnoyarsk), Konstantin Rachkov (Stade Phoceen, France), Alexander Yanyushkin (VVA-Podmoskovye, Monino) (capt); Sergey Popov (Slava-ShVSM, Moscow), Valery Tsnobiladze (Novokuznetsk, Novokuznetsk), Alexander Khrokin (VVA-Podmoskovye, Monino), Denis Antonov (Slava-ShVSM, Moscow), Adam Byrnes (Melbourne Rebels, Australia), Artem Fatakhov (VVA-Podmoskovye, Monino), Andrey Garbuzov (Krasniy Yar, Krasnoyarsk), Victor Gresev (VVA-Podmoskovye, Monino),
Replacements: Evgeny Matveev (VVA-Podmoskovye, Monino), Ivan Prishchepenko (Krasniy Yar, Krasnoyarsk), Alexey Travkin (VVA-Podmoskovye, Monino), Alexander Voytov (VVA-Podmoskovye, Monino), Andrey Bykanov (Slava-ShVSM, Moscow), Mikhail Sidorov (Slava-ShVSM, Moscow), Mikhail Babaev (VVA-Podmoskovye, Monino)