Ireland coach Declan Kidney has made 10 changes, one positional, for Sunday's Rugby World Cup Pool C game with Russia in Rotorua.
Right winger Fergus McFadden is one of four Rugby World Cup debutants, with Keith Earls moving from the wing to outside centre, where he will play alongside Paddy Wallace, who will also be making his first appearance of the tournament.
Andrew Trimble starts on the left wing, with Ronan O'Gara and Isaac Boss forming the half-back partnership.
Hooker Sean Cronin replaces Rory Best for his tournament bow, alongside tighthead prop Tony Buckley, who makes his first start of the tournament.
In the back row, Donnacha Ryan replaces Stephen Ferris at blindside flanker.
Leo Cullen plays in the second row instead of Paul O'Connell, and will captain the side.
Injuries mean Russia have been forced to make nine changes, one of which is positional, from the side that scored three tries in the 53-17 loss to Italy in Nelson on Tuesday.
Scrum-half Alexander Yanyushkin, who impressed after coming on against Italy, starts in place of Vladislav Korshunov and also takes over as captain.
He will play alongside Konstantin Rachkov in the half-back.
Former Leinster player Vasily Artemyev keep his place in the backs but moves from right wing to full-back.
That allows highly-rated 20-year-old Siberian Denis Simplikevich to come into the side.
Another player making his first Rugby World Cup appearance is experienced inside centre Sergey Trishin, who was a late addition to the squad.
Up front prop Sergey Popov returns alongside Valeriy Tsnobiladze and Alexey Khrokin, who will become Russia's most capped forward as he makes his 75th appearance.
Denis Antonov and former Leinster Adam Byrnes form the second row partnership, with a back row of Victor Gresev, Artem Fatakhov and Andrey Garbuzov.
Ireland: Rob Kearney (UCD); Fergus McFadden (Old Belvedere), Keith Earls (Young Munster), Paddy Wallace (Ballymena), Andrew Trimble (Ballymena); Ronan O'Gara (Cork Constitution), Isaac Boss (Terenure College); Cian Healy (Clontarf), Sean Cronin (Leinster), Tony Buckley (Sale Sharks), Donncha O'Callaghan (Cork Constitution), Leo Cullen (Blackrock College, capt), Donnacha Ryan (Shannon), Sean O'Brien (Clontarf), Jamie Heaslip (Naas)
Replacements: Rory Best (Banbridge), Mike Ross (Clontarf), Dennis Leamy (Cork Constitution), Shane Jennings (St.Mary's College), Eoin Reddan (Lansdowne/Leinster), Jonathan Sexton (St. Mary's College), Geordan Murphy (Leicester Tigers)
Russia: Vasily Artemyev (Northampton Saints), Denis Simplikevich (Enisey-STM, Krasnoyarsk), Andrey Kuzin (VVA-Podmoskovye, Monino), Sergey Trishin (VVA-Podmoskovye, Monino), Vladimir Ostroushko (Enisey-STM, Krasnoyarsk), Konstantin Rachkov (Stade Phoceen, France), Alexander Yanyushkin (VVA-Podmoskovye, Monino) (capt); Sergey Popov (Slava-ShVSM, Moscow), Valery Tsnobiladze (Novokuznetsk, Novokuznetsk), Alexander Khrokin (VVA-Podmoskovye, Monino), Denis Antonov (Slava-ShVSM, Moscow), Adam Byrnes (Melbourne Rebels, Australia), Artem Fatakhov (VVA-Podmoskovye, Monino), Andrey Garbuzov (Krasniy Yar, Krasnoyarsk), Victor Gresev (VVA-Podmoskovye, Monino),
Replacements: Evgeny Matveev (VVA-Podmoskovye, Monino), Ivan Prishchepenko (Krasniy Yar, Krasnoyarsk), Alexey Travkin (VVA-Podmoskovye, Monino), Alexander Voytov (VVA-Podmoskovye, Monino), Andrey Bykanov (Slava-ShVSM, Moscow), Mikhail Sidorov (Slava-ShVSM, Moscow), Mikhail Babaev (VVA-Podmoskovye, Monino)
Scotland coach Andy Robinson has signalled his side's intent to run the ball at Argentina on Sunday with his selection of Ruaridh Jackson at fly-half.
While many might have expected Dan Parks to retain the number 10 jersey having enjoyed success against the Pumas in the past, Robinson said Jackson's ability to take on the line and feed his backs had earned him the selection for the crucial Pool B contest in Wellington.
"He has a very good ability to go to the line and challenge defences," said Robinson.
"We believe going into this game it's important for us to play with ball in hand as well as have the balanced game of kicking.
"We want to bring our dangerous runners like Max Evans, Sean Lamont, Chris Paterson and Graeme Morrison into the game."
Jackson's selection and the dropping of captain Alastair Kellock were the main talking points following the announcement of the team which shows five changes to the one that scraped past Georgia 15-6 in Invercargill.
Scrum-half Rory Lawson will captain the side in Kellock's absence.
The return of Paterson at full-back is the only other change in the backline.
Jim Hamilton and Richie Gray come into the second row in place of Kellock and Nathan Hines, while prop Geoff Cross replaces Euan Murray, who does not play rugby on a Sunday for religious reasons.
First-choice open-side flanker John Barclay also returns, taking over from Ross Rennie.
Robinson admitted the decision to drop Kellock had been a tough one but he felt that Hamilton would provide the power in the scrum and Gray the mobility to counter a strong Pumas pack.
"Euan is our best scrummager and Euan is not playing in this game so putting some real weight behind Geoff Cross on that right hand side that's what Jim Hamilton gives us," explained Robinson.
"Jim has led the line-out well in the game he played in [against Georgia] but also in the Ireland match in the warm-ups.
"Then it's putting together a second row that could work with Jim that could give us the ability to play quickly.
"I believe Richie Gray, who is an outstanding second-row forward, has that ability to work for us in open play with his athleticism."
Scotland and Argentina have faced each other five times since the last World Cup, with the Scots winning three of those contests including a historic series win in South America last year.
With Argentina already losing to England, the Pumas know that they need victory on Sunday to have any chance of reaching the last eight.
Scotland team: Chris Paterson; Max Evans, Nick De Luca, Graeme Morrison, Sean Lamont; Ruaridh Jackson, Rory Lawson (captain); Allan Jacobsen, Ross Ford, Geoff Cross, Richie Gray, Jim Hamilton, Alasdair Strokosch, John Barclay, Kelly Brown.
Replacements: 16. Dougie Hall, 17. Alasdair Dickinson, 18. Nathan Hines, 19. Richie Vernon, 20. Mike Blair, 21. Dan Parks, 22. Simon Danielli.