Fly-half Stephen Jones is poised to become Wales' most capped player after being named in the side to take on Namibia on Monday.
The 33-year-old Scarlets number 10 has recovered from the calf injury that ruled him out of the World Cup warm-up game against England last month and will now win his 101st cap.
He currently shares the record with Gareth Thomas.
"It is great being back with the guys, trying to get up to speed with all the moves and the game plan and just enjoying being integrated with the squad again," he said.
Coach Warren Gatland has revamped his starting XV, with only four players surviving from the team that defeated Samoa last time out.
Centre Jonathan Davies, lock Alun Wyn Jones, open-side flanker Sam Warburton and number eight Toby Faletau are the only players retained.
Ryan Jones, who has also been suffering with a calf problem, returns to the blind-side flank in place of the injured Dan Lydiate.
Full-back Lee Byrne takes over from James Hook, who has a shoulder injury, while Scott Williams comes into the midfield.
Loose-head prop Gethin Jenkins, who has had a calf injury, makes his first start since the defeat by New Zealand in November last year.
Scarlets scrum-half Tavis Knoyle takes the number nine shirt as Mike Phillips is rested for the game against Namibia, who were beaten 87-0 by South Africa on Thursday.
"On the back of two tough and intensely physical matches we have been able to make some changes to the squad but also bring a lot of experience into the side at the same time," said Wales coach Warren Gatland.
"Stephen, Ryan and Gethin in particular bring a wealth of experience but we have some previously established combinations elsewhere in the side as well, in the second row, the midfield and at halfback, so we are excited and looking for this side to do well against Namibia.
"Namibia will be hurting after their loss to South Africa, but we will be concentrating on ourselves and our own performance.
"This is the rugby World Cup and every performance counts, we showed great heart and courage last week to grind out a win and this week we need to do similar, but also improve and take that next step towards qualification from this incredibly tough group."
Wales team: Lee Byrne; Leigh Halfpenny, Jonathan Davies, Scott Williams, Aled Brew; Stephen Jones, Tavis Knoyle; Gethin Jenkins, Lloyd Burns, Craig Mitchell, Bradley Davies, Alun Wyn Jones, Ryan Jones, Sam Warburton (c), Toby Faletau.
Replacements: Ken Owens, Ryan Bevington, Luke Charteris, Andy Powell, Lloyd Williams, Rhys Priestland, George North.