Almost 26,000 spectators went to Upton Park in midweek looking to see the Hammers progress to the last 16 of the Capital One Cup, but instead they saw a young side collapse to a comprehensive defeat.
Allardyce made nine changes to his side, giving the likes of Ricardo Vaz Te, George McCartney and James Tomkins a chance to impress, but Wigan tore up West Ham's unbeaten home record with a 4-1 win that came thanks to goals from Ivan Ramis, Jordi Gomez and a splendid double from Mauro Boselli.
Allardyce hit out at his team's efforts after the game, describing their defensive performance as "comical", and it appears the West Ham boss is still fuming at the result.
"I've had a few days to reflect on our 4-1 Capital One Cup defeat at home to Wigan and I'm still just as upset as straight after the match," Allardyce told the London Evening Standard.
"What really disappoints me is that, after all the hard work we put in during pre-season and such a fantastic start, we offered up a performance like that.
"I just don't accept what happened in any shape or form and the players are putting their West Ham careers in jeopardy.
"Someone on TV made the point that, of the Manchester United squad which lost to Crystal Palace in the League Cup last November, nine players have since left the club.
"It's a similar scenario at most clubs. If you get a chance you have to grab it because everyone must realise that time is short these days."
Allardyce has now called on his players to lift the spirits of the fans who were unfortunate enough to watch the Wigan game by beating QPR at Loftus Road in the Barclays Premier League on Monday night.
He said: "The players didn't give good value for money against Wigan.
"Now we have to make sure that we send them home happy on Monday night by getting a good result against QPR."
Allardyce may decide to retain Modibo Maiga after he scored the only goal of the game on Tuesday, but otherwise the team is expected to change almost entirely.
Winston Reid, James Collins and Kevin Nolan will come back in and there could be a first start for Yossi Benayoun since he returned to the club on loan from Chelsea.
Andy Carroll, who injured his hamstring on debut against Fulham at the start of the month, is likely to miss out, but Gary O'Neil, who suffered a knee injury on Tuesday, is fit.