Jean-Louis Akpa Akpro hit a second-half double as Tranmere extended their lead at the top of League One to four points with a a 3-1 win over struggling Scunthorpe at Glanford Park.
Karl Hawley's 15th-minute header had put the home side in front on 15 minutes but James Wallace headed a 62nd-minute equaliser before Akpa Akpro netted on 64 and 88 to seal Rovers' win.
Tranmere's good night got better as all three clubs who started the night immediately behind them in the table failed to win, with Notts County stunned by a late brace in a 2-1 home defeat to Stevenage.
Jamal Campbell-Ryce put County ahead with a 71st-minute penalty after Jeff Hughes had missed an earlier spot-kick.
But Stevenage equalised with a Lucas Akins spot-kick on 83 after Alan Sheehan was sent off for deliberate hand-ball, and the visitors snatched the points deep into injury time with a strike from substitute Robin Shroot.
Milton Keynes Dons failed to capitalise on County's misfortune as they were held to a 1-1 draw at Coventry.
Richard Wood headed home a Gary McSheffrey corner to put the home side in front on 34 minutes, but Stephen Gleeson equalised for the Dons before half-time.
Swindon were beaten 1-0 at home by struggling Colchester, for whom Michael Rose scored a 70th-minute winner.
And Walsall were also shocked at home by Leyton Orient, early goals from Lee Cook and Dean Cox sending the O's on the way to the points before Will Grigg made the final score 2-1 with a 57th-minute penalty.
Crawley's strong start continued with a 3-1 win over Bournemouth, Hope Akpan and Joe Walsh giving the home side a first-half lead and adding a third through Nicky Adams after Lee Barnard had reduced the deficit.
Paul Gallagher's 89th-minute winner gave Sheffield United a 2-1 win over Hartlepool at Victoria Park. Dave Kitson put the Blades in front with a 27th-minute header but veteran Steve Howard thought he had salvaged a point with a header of his own 12 minutes from time.
Goals from Jack King, Scott Laird and Stuart Beavon sent Preston to a 3-1 win at Doncaster, for whom David Cotterill had briefly equalised from long range.
Gabor Gyepes scored late to give Portsmouth a 2-1 win at Yeovil, for whom Reuben Reid's penalty had cancelled out an early Izale McLeod opener.
Second-half goals from James Tarkowski and Matt Derbyshire helped Oldham to a 2-0 win at Crewe, while Brentford against Shrewsbury finished goalless.