With top spot in Group D up for grabs, Borussia Dortmund will be hoping Real Madrid`s disjointed defence will buckle at their mercy on Wednesday.
Madrid are currently in disarray across the back line, with Marcelo, Alvaro Arbeloa and Fabio Coentrao all sidelined.
As a result, coach Jose Mourinho took on Celta Vigo at the weekend with midfielder Michael Essien at left-back, centre-half Sergio Ramos at right-back and rookie Raphael Varane in the middle.
The return of defensive midfielder Sami Khedira should help Madrid`s cause in Germany, but he accepts it will be no easy night.
"I think that Dortmund are a great team, but so are Manchester City," he said, first assessing the state of the group.
"I believe that all three teams - and also Ajax - are great teams, so we cannot afford to focus only on Borussia.
"But, if we win, it`s clear we will have taken a big step towards classification as first in the group.
"Dortmund are a compact team, they play in a block and also at great pace for 90 minutes. They are disciplined tactically, and have a lot of quality, especially in attack."
Dortmund will be taking to their home ground of Signal Iduna Park for the first time since the weekend`s bad-tempered clash with Schalke.
Crowd violence marred the derby game but, according to former Stuttgart midfielder Khedira, it is an exciting place to play.
"It`s a special time, because the atmosphere is always unique in Germany," he said.
"Playing at Dortmund is always nice, because it has a special atmosphere. The atmosphere of champions."
Dortmund were considered to be mightily unlucky not to take all three points from their last outing at Manchester City.
A brilliant display of goalkeeping by Joe Hart prevented them from adding to their goal, before a late, controversial penalty made it 1-1.
A league loss to Schalke is their most recent form, though, and manager Jurgen Klopp said: "We did not play well against Schalke, but there is nothing we can do to change that.
"The match against Real Madrid remains a cool match."
Key midfielder Jakub Blaszczykowski will be missing again for Dortmund, but left-back Marcel Schmelzer, midfielder Ilkay Guendogan and playmaker Mario Goetze are set to return.