Ben Watson (broken leg), Gary Caldwell (hamstring), Ryo Miyaichi (ankle) and Franco Di Santo (leg) all suffered injuries in last weekend's 3-0 defeat by Liverpool, although strikers Miyaichi and Di Santo will be assessed ahead of the match and could still feature.
Midfielder James McArthur (dead leg), winger Albert Crusat (knee) and defender Antolin Alcaraz (groin) are not yet ready to return, although Crusat is expected to back at the start of next month and Alcaraz is getting closer to returning to full training.
Reading manager Brian McDermott could welcome Jimmy Kebe back into his squad for the trip to Wigan.
Kebe missed last weekend's win over Everton with a groin problem but has returned to training and is in contention for the match at the DW Stadium.
McDermott has also welcomed goalkeeper Alex McCarthy back to training, along with midfielders Danny Guthrie and Jem Karacan, although tomorrow's game will be too early for any of them to return.
Wigan: Al Habsi, Pollitt, Ramis, Figueroa, Beausejour, Boyce, McCarthy, Maloney, Kone, Boselli, Gomez, Jones, McManaman, Fyvie, Lopez, Stam, Di Santo, Miyaichi.
Reading: Federici, Taylor, Gunter, Cummings, Gorkss, Pearce, Morrison, Mariappa, Shorey, Harte, McAnuff, Leigertwood, Tabb, McCleary, Kebe, Pogrebnyak, Le Fondre, Hunt, Robson-Kanu, Roberts.