Blue and red collide in Manchester on Sunday for yet another key showdown between England's top two.
But this fixture has not required City and United to be challenging for honours for the fare to be interesting.
Here, we look at six of the best derby tussles.
April 27, 1974: Manchester United 0 Manchester City 1
United would have gone down anyway, no matter what the result of this game. But that defeat to their old rivals confirmed it, and Denis Law scored with a cheeky backheel that merely twisted the knife a little bit more.
September 23, 1989: Manchester City 5 Manchester United 1
Sir Alex Ferguson claimed this was the worst defeat of his career. Under pressure and struggling to make an impact, the Scot's new-look side was dismantled by a rampant City. David Oldfield scored twice, with Trevor Morley and Ian Bishop also finding the net before Andy Hinchcliffe completed the rout.
November 7, 1993: Manchester City 2 Manchester United 3.
Two-up through a Niall Quinn double, City supporters were in ecstasy at half-time. But Eric Cantona pulled one back for the visitors straight after the break, then equalised before Roy Keane completed a remarkable comeback to silence the Maine Road faithful.
November 10, 1994: Manchester United 5 Manchester City 0.
United in their pomp and City beginning their slide to oblivion. Andrei Kanchelskis scored the first derby hat-trick for 24 years after Cantona and Hughes had put United in command.
September 20, 2009: Manchester United 4 Manchester City 3.
A quite unbelievable game, settled by Michael Owen in the sixth minute of stoppage time. Wayne Rooney opened the scoring before Gareth Barry capitalised on a Ben Foster mistake. Darren Fletcher and Craig Bellamy both scored twice, with City believing they had earned a share of the spoils until Owen's best moment in a United shirt.
October 23, 2011. Manchester United 1 Manchester City 6.
One of those days no-one will ever forget. Mario Balotelli's opener, before revealing that 'Why Always Me' T-shirt started a riot the like of which had never been seen. The Italian added another, Sergio Aguero put City three up, then, after Darren Fletcher had pulled one back, Edin Dzeko (2) and David Silva netted in stoppage time to condemn United to their worst home defeat since 1955.