Manager Phil Parkinson will ring the changes as Bradford look to maintain their incredible record in knockout competitions when they travel to Brentford for their second-round replay.
The Bantams have yet to taste defeat in a cup competition this term, going 10 games unbeaten across the Capital One Cup, Johnstone's Paint Trophy and FA Cup.
However, the downside to such an impressive run is that Parkinson's men have had to negotiate their way through a series of gruelling fixtures, some of which have included extra-time and penalty shoot-outs.
Bradford were reinstated in the FA Cup on appeal last week, having been expelled by the Football Association for fielding on-loan Curtis Good in the first meeting with Brentford when he was ineligible to play, but despite the second chance Parkinson knows he has to use his resources wisely.
Speaking to the Bantams' official website, he said: "I have told both of our chairmen our plans for Tuesday and they are happy and understand that we are going to make as many changes as possible.
"That will include having some of the youth team players with us.
"We have to manage the lads properly with the amount of games we've had already and the amount of games we have coming up in this next month or so.
"We will be going to Brentford looking to put a good performance in, as we always do, but I have to be fair to some of our players."
Midfielder Nathan Doyle is one of the first-team regulars who definitely will not feature as he serves a one-match ban following a fifth booking of the season at Southend on Saturday. In-form striker Nahki Wells, who took his tally to 15 for the season against the Shrimpers, may be among those rested after struggling with a knee problem of late.
Will Atkinson has had to contend with a hip problem while fellow midfielder Gary Jones, 35, played the entire game of Bradford's historic spot-kick success over Barclays Premier League giants Arsenal.
Brentford are without loanees Rob Kiernan, Marcello Trotta and Lee Hodson after all were denied permission to play by their parent clubs. The winner of the replay at Griffin Park will travel to Southend in the third round.
Oxford defender Michael Duberry could make his first-team return in the replay against Accrington.
The experienced centre-back-has not played this campaign after suffering a serious neck injury at the end of last season, but has made good progress in recent weeks and is now back in full training. The winners of that tie are at home to Sheffield United in round three.
Barrow and Macclesfield will make a third attempt to play their second-round tie after two earlier postponements, with a home clash against Cardiff the reward for the winners. Notts County and Rotherham meet at Meadow Lane with Aldershot awaiting the victors.