Bale picked up his third yellow card of the season for simulation in Saturday's win at Sunderland - his fifth domestic caution overall - and will sit out tomorrow's Premier League game.
The trip to the Stadium of Light came too soon for Clint Dempsey (groin) and Benoit Assou-Ekotto (knee) but the fit-again Scott Parker made another substitute appearance and Tom Huddlestone was on the bench.
The Royals have taken four points from their previous two Barclays Premier League fixtures and, despite the fixture pile-up, McDermott could keep faith with the side who have faired well of late.
Defender Sean Morrison returned to the bench for Saturday's win over West Ham after recovering from an ankle injury, although Jason Roberts (hip) is unlikely to feature with Alex McCarthy (shoulder) a long-term absentee.
Spurs: Friedel, Lloris, Walker, Naughton, Assou-Ekotto, Gallas, Caulker, Dawson, Vertonghen, Lennon, Sigurdsson, Livermore, Sandro, Huddlestone, Dembele, Parker, Dempsey, Adebayor, Defoe.
Reading: Federici, Taylor, Gunter, Cummings, Gorkss, Pearce, Morrison, Mariappa, Shorey, Harte, McAnuff, Guthrie, Leigertwood, Tabb, Karacan, Kebe, McCleary, Robson-Kanu, Le Fondre, Hunt, Pogrebnyak.