Tottenham midfielder Scott Parker could make his first Barclays Premier League start of the season against league leaders Manchester United on Sunday.
Brazil international Sandro has been ruled out for the rest of the season after suffering knee ligament damage in the draw at QPR last weekend and Parker, who has not started a league game since April, is likely to replace him.
Striker Emmanuel Adebayor has now left for the African Nations Cup while defenders William Gallas (calf) and Younes Kaboul (knee) remain absent.
Provisional squad: Lloris, Friedel, Gomes, Walker, Naughton, Dawson, Vertonghen, Caulker, Assou-Ekotto, Lennon, Sigurdsson, Falque, Townsend, Livermore, Dempsey, Carroll, Mason, Huddlestone, Parker, Dembele, Bale, Defoe.
Jonny Evans again misses out as Manchester United visit Tottenham on Sunday.
Manager Sir Alex Ferguson had hoped the Northern Ireland international would have shrugged off a slight hamstring strain but Evans was unable to train this morning and has been ruled out.
Plenty of changes are anticipated following the midweek FA Cup win over West Ham, with Robin van Persie amongst those set to return.
Team (from): Lindegaard, De Gea, Amos, Smalling, Vidic, Ferdinand Evans, Buttner, Evra, Cleverley, Giggs, Fletcher, Anderson, Scholes, Carrick, Kagawa, Nani, Hernandez, Rooney, Welbeck, Van Persie.