Wayne Rooney is set to miss Manchester United's trip to basement boys QPR.
Rooney sat out Monday's FA Cup win over Reading with a sinus problem and although he has now returned to training, United manager Sir Alex Ferguson does not expect the striker to have fully recovered for the Loftus Road encounter.
Phil Jones (ankle) and Paul Scholes (knee) are also sidelined although Ferguson will still make changes, with Robin van Persie amongst those likely to be recalled.
QPR's Loic Remy is a doubt for the Premier League clash with Manchester United.
The France forward has been struggling with a groin complaint and, having suffered a setback, will be assessed to see whether he is available at Loftus Road.
Junior Hoilett (hamstring) and Samba Diakite (international duty) are available again, while manager Harry Redknapp is hoping to get more than 45 minutes from Bobby Zamora as the forward manages a long-standing hip injury.
QPR: Cesar, Green, Murphy, Onuoha, Hill, Ben Haim, Samba, Mbia, Fabio, Traore, Granero, Diakite, Hoilett, Park, Derry, Taarabt, Jenas, Townsend, Wright-Phillips, Mackie, Remy, Bothroyd, Zamora.
Man United: De Gea, Lindegaard, Amos, Rafael, Smalling, Ferdinand, Vidic, Evans, Evra, Buttner, Nani, Valencia, Carrick, Cleverley, Giggs, Anderson, Young, Kagawa, Welbeck, Hernandez, Van Persie.