Gary Cahill and Cesar Azpilicueta will both miss Chelsea's FA Cup fifth round tie at Middlesbrough on Wednesday.
Centre-back Cahill has been struck down by a virus ahead of the trip to the Riverside, while right-back Azpilicueta is sidelined with discomfort in his leg.
Interim manager Rafael Benitez plans to rotate his squad in a bid to deal with the busy fixture list, meaning captain John Terry may be rested. Long-term absentee Oriol Romeu continues to miss out with a knee injury.
Chelsea: Cech, Turnbull, Hilario, Ivanovic, Ferreira, Cole, Bertrand, Luiz, Terry, Ake, Oscar, Mata, Moses, Mikel, Lampard, Ramires, Hazard, Marin, Benayoun, Torres, Ba.