Ryan Giggs will sit out Manchester United's FA Cup quarter-final with Chelsea on Sunday.
Giggs is not required by manager Sir Alex Ferguson following his outstanding performance against Real Madrid, so his wide berth is likely to go to Antonio Valencia or Ashley Young.
Phil Jones (ankle) and Paul Scholes (knee) are definitely out, while the main focus will be on whether Wayne Rooney gets a start after being left on the bench against Madrid.
Chelsea captain John Terry and striker Fernando Torres could make way as Rafael Benitez again rotates his squad for Sunday's FA Cup quarter-final at Manchester United.
Terry, whose fitness travails mean he is unlikely to be asked to play twice in four days, and Torres played in last night's Europa League loss at Steaua Bucharest.
Demba Ba, Victor Moses, Ramires and Nathan Ake return to the squad after missing the trip to Romania, while Oriol Romeu (knee) remains a long-term absentee.
Man Utd: De Gea, Lindegaard, Amos, Rafael, Smalling, Ferdinand, Vidic, Evans, Evra, Buttner, Nani, Valencia, Carrick, Cleverley, Anderson, Young, Kagawa, Welbeck, Rooney, Hernandez, Van Persie.
Chelsea: Cech, Turnbull, Hilario, Ivanovic, Ferreira, Cole, Bertrand, Luiz, Terry, Cahill, Azpilicueta, Ramires, Oscar, Mata, Benayoun, Mikel, Moses, Lampard, Hazard, Marin, Torres, Ba, Ake.