Callum McManaman will miss Wigan's final game of the season against Aston Villa on Sunday after suffering an ankle injury in the 4-1 defeat by Arsenal on Tuesday that condemned the Latics to relegation.
Forward McManaman has damaged ankle ligaments and, although he does not need an operation, manager Roberto Martinez expects him to be out for up to three months, meaning he will also miss the European Under-21 Championships in Israel next month.
Martinez has concerns over a couple of knocks and niggles while wing-back Jean Beausejour will hope to return from a hamstring problem.
Aston Villa will be without suspended striker Christian Benteke for Sunday's final match of the season.
The 19-goal forward has a ban to serve following his dismissal for two bookings in last weekend's defeat by Chelsea, possibly handing Darren Bent a rare start.
Right-back Matthew Lowton could return following a thigh problem while midfielder Karim El Ahmadi (also thigh) is back in contention, but defender Ciaran Clark (foot) misses out.
Wigan: Robles, Boyce, Alcaraz, Scharner, Gomez, Watson, Espinoza, McArthur, McCarthy, Maloney, Kone, Al Habsi, Henriquez, Golobart, Caldwell, Di Santo, Fyvie, Beausejour.
Aston Villa: Guzan, Given, Lowton, Vlaar, Lichaj, Stevens, Baker, Bennett, Sylla, Ireland, Gardner, Westwood, Dawkins, N'Zogbia, El Ahmadi, Bannan, Holman, Agbonlahor, Bent, Bowery, Weimann.