Crystal Palace manager Ian Holloway will not be able to hand a debut to summer signing Jerome Thomas when the Eagles welcome Tottenham to Selhurst Park for their Barclays Premier League curtain-raiser on Sunday.
The 30-year-old winger suffered an ankle injury in a friendly against Lazio last weekend and is set to be sidelined for at least two weeks.
However, a host of other new signings could be in line for their competitive debuts with the likes of Marouane Chamakh and Elliott Grandin likely to be involved. Captain Paddy McCarthy (groin) is back in training but will not be ready while Glenn Murray (knee) and Yannick Bolasie (hamstring) are also absent.
Wantaway Tottenham forward Gareth Bale has been ruled out of Sunday's game at Crystal Palace because of a foot injury.
Defender Jan Vertonghen is doubtful due to an ankle injury he suffered in pre-season while midfielder Lewis Holtby misses out with a knee injury.
Striker Emmanuel Adebayor will not feature as he only returned from compassionate leave on Wednesday while midfielder Scott Parker is expected to be left out of the squad as he is in talks with other clubs about a move away from White Hart Lane.
Palace: Speroni, Alexander, Price, Ward, Parr, Blake, Moxey, Delaney, Ramage, Gabbidon, Dikgacoi, Garvan, Jedinak, Williams, Campana, Grandin, Dobbie, Wilbraham, Phillips, Chamakh.
Spurs: Lloris, Friedel, Gomes, Walker, Naughton, Assou-Ekotto, Rose, Fryers, Dawson, Kaboul, Vertonghen, Capoue, Sandro, Paulinho, Dembele, Carroll, Lennon, Chadli, Townsend, Sigurdsson, Soldado, Defoe, Kane.