New signings Christian Eriksen and Erik Lamela look set to make their first starts for Tottenham in Saturday's home game against Norwich.
Midfielders Etienne Capoue (ankle) and Aaron Lennon (foot) are out and Vlad Chiriches is also unavailable as Spurs are still to get a work permit for the Romanian defender.
Forward Gylfi Sigurdsson (leg) is a minor doubt and striker Emmanuel Adebayor will not feature as he has been given permission to remain on leave in Togo until Monday for personal reasons.
Provisional squad: Lloris, Friedel, Gomes, Walker, Naughton, Dawson, Kaboul, Vertonghen, Fryers, Rose, Sandro, Dembele, Eriksen, Paulinho, Holtby, Townsend, Chadli, Sigurdsson, Lamela, Soldado, Defoe, Kane.
Striker Gary Hooper came through training this week and could make his debut in the Norwich squad after recovering from a shin problem.
Defender Ryan Bennett is fit again after needing stitches in a gashed left knee, an injury sustained in the Capital One Cup victory against Bury.
Manager Chris Hughton reported no problems among the 11 Norwich players who returned from international duty. Midfielder Elliott Bennett, meanwhile, is recovering from surgery on a cruciate ligament injury.
Provisional squad: Ruddy, Whittaker, Martin, Turner, Garrido, Howson, Johnson, Redmond, Hoolahan, Van Wolfswinkel, Snodgrass, Elmander, Fer, Bassong, Hooper, Pilkington, Bunn, Becchio, Olsson, Ryan Bennett, Fox, Ayala, Tettey.