Liverpool defender Daniel Agger is expected to return to face Southampton after missing Monday's draw at Swansea with a side strain.
Playmaker Philippe Coutinho is out for several weeks after undergoing a shoulder operation so the likes of Iago Aspas and Raheem Sterling will be pushing for a recall.
The match marks the completion of striker Luis Suarez's 10-game ban, which carried over from last season.
Southampton left-back Luke Shaw is fit for the Barclays Premier League trip to Liverpool.
The teenager limped off in last weekend's 0-0 draw with West Ham, but Mauricio Pochettino has revealed he has overcome that knock.
Fellow left-back Danny Fox remains a doubt with an ankle complaint and Tadanari Lee may also miss out.
Liverpool: Mignolet, Wisdom, Toure, Agger, Enrique, Lucas, Gerrard, Henderson, Moses, Aspas, Sterling, Sturridge, Jones, Skrtel, Kelly, Alberto, Allen, Ibe.
Southampton: Boruc, Davis, Gazzaniga, Clyne, Chambers, Shaw, Fox, Lovren, Hooiveld, Yoshida, Fonte, Schneiderlin, Cork, Davis, Ward-Prowse, Wanyama, Lallana, Rodriguez, Ramirez, Do Prado, Osvaldo, Lambert, Lee.