Robin van Persie will miss Manchester United's League Cup third-round tie with Liverpool at Old Trafford.
Van Persie has not recovered from the groin injury that kept him out of Sunday's Premier League defeat at Manchester City.
Manager David Moyes is expected to make changes, with Javier Hernandez, Jonny Evans, Shinji Kagawa, Wilfried Zaha and Anders Lindegaard amongst those hoping to be involved.
Striker Luis Suarez returns after his 10-match ban but manager Brendan Rodgers has yet to decide whether he will start.
Centre-back Daniel Agger is unlikely to be risked as he is still struggling with a side strain which forced him off in Saturday's defeat to Southampton.
Kolo Toure seems the obvious choice to take his place, meaning Rodgers has decisions to make at full-back with Jose Enrique looking to return on the left and Andre Wisdom and Martin Kelly vying for a place on the right.
Man United: De Gea, Lindegaard, Amos, Rafael, Fabio, Jones, Smalling, Ferdinand, Vidic, Evra, Buttner, Thorpe, Valencia, Giggs, Carrick, Cleverley, Fellaini, Anderson, Kagawa, Nani, Young, Cole, Welbeck, Rooney, Hernandez, Keane.
Liverpool: Mignolet, Wisdom, Kelly, Toure, Skrtel, Enrique, Gerrard, Lucas, Henderson, Moses, Suarez, Sturridge, Jones, Sakho, Allen, Alberto, Sterling, Aspas, Ibe.