Hull winger Robbie Brady will undergo surgery on Tuesday after pulling out of the Republic of Ireland squad with a groin injury.
The 21-year-old was called up by interim Republic manager Noel King for this month's World Cup qualifiers against Germany and Kazakhstan, but had on Saturday aggravated an existing groin complaint during a 1-0 victory over West Ham, in which he fired the only goal from the penalty spot.
A scan conducted on Monday evening determined Brady needed an operation on his groin and ruled him out of contention, the Football Association of Ireland confirmed in a statement.
Andy Reid, Darron Gibson, Anthony Stokes could all feature, though, after being recalled from the international wilderness following Giovanni Trapattoni's departure as Republic boss. Wolves striker Kevin Doyle was also included in King's group.
Nottingham Forest midfielder Reid was eventually discarded by Trapattoni after the pair clashed at the team hotel in the wake of a 2-1 World Cup qualifier victory over Georgia in September 2008.
Celtic frontman Stokes was similarly ostracised when he pulled out of a Carling Nations Cup game in May 2011 citing fatigue, while Doyle, once a favourite of the 74-year-old Italian, lost his place as his confidence dipped along with club Wolves' fortunes.
Gibson's exile was self-imposed after he was left sitting on the bench for the entire Euro 2012 finals campaign in Poland, although he revealed earlier this month that he would make himself available once again after Trapattoni's exit.
Midfielder Stephen Ireland has indicated his willingness to return too, but not until he has re-established himself in club football following his loan move to Stoke.
The players will begin their preparations in Malahide on Monday and King, who has stepped up from his role as Under-21s manager, is relishing the opportunity to work with them.
He said: "I spoke to a lot of the players over the past week and everyone is looking forward to coming in.
"Playing against the third-ranked team in the world is always going to be a big challenge, but it is the sort that every player wants to be a part of.
"It is a natural ambition to try to win every game and these two games should be no different."
King named a 26-man party for the two games - prior to Brady's withdrawal - although he has a further injury doubt over Stoke striker Jon Walters, who also has a groin problem.
Central defenders Richard Dunne and John O'Shea are both suspended for the Germany game in Cologne on October 11, but will return to the squad for the home clash with Kazakhstan four days later.