Lucas Leiva is suspended for the visit of Crystal Palace so Liverpool manager Brendan Rodgers has to find a replacement in central midfield.
Jordan Henderson, who has operated predominantly on the right this season, is the most likely candidate to switch to the centre.
Depending on which formation Rodgers opts for that could mean an opening for the likes of Martin Kelly, Raheem Sterling or Luis Alberto.
Yannick Bolasie could make his first appearance of the season when Crystal Palace head to Liverpool in the Barclays Premier League on Saturday.
The winger will travel to Anfield having recovered from a torn hamstring, while defender Damien Delaney should also be in the squad after shaking off an ankle knock.
But boss Ian Holloway revealed two of his starting XI from the 2-0 defeat at Southampton last week are set to miss out through injury, although he would not specify the players concerned.
Liverpool: Mignolet, Toure, Skrtel, Sakho, Kelly, Henderson, Gerrard, Enrique, Moses, Sturridge, Suarez, Jones, Wisdom, Agger, Ilori, Alberto, Aspas, Sterling, Ibe.
Crystal Palace: Speroni, Gabbidon, Moxey, Delaney, Mariappa, Campana, Guedioura, Bannan, Thomas, Jedinak, Dikgacoi, Chamakh, Jerome, Gayle, Puncheon, O'Keefe, Bolasie, Phillips, Kebe, Price.