Hull are without top-scorer Robbie Brady for the Barclays Premier League visit of Aston Villa after the Republic of Ireland international underwent a hernia operation on Wednesday.
Brady, who has netted four times this season, is out for around four weeks, joining long-term absentees Robert Koren (fractured foot) and James Chester (hamstring) on the sidelines.
One of Stephen Quinn or George Boyd will replace Brady, while the fit-again Paul McShane could replace Abdoulaye Faye at centre-half.
Gabriel Agbonlahor and Ashley Westwood could return from recent injuries when Aston Villa head to Hull on Saturday.
Striker Agbonlahor's recent run of form has been interrupted by an ankle issue while midfielder Westwood has been out with a thigh problem, but both men are in contention to feature at the KC Stadium.
However, Paul Lambert will be without striker Christian Benteke (hip) while defender Jores Okore (cruciate ligament) and midfielder Charles N'Zogbia (Achilles) are long-term absentees.
Hull: McGregor, Harper, McShane, Faye, Davies, Rosenior, Elmohamady, Bruce, Boyd, Quinn, Huddlestone, Livermore, Meyler, Graham, Aluko, Sagbo, Proschwitz, Gedo.
Aston Villa: Guzan, Steer, Baker, Bennett, Vlaar, Clark, Luna, Lowton, Bacuna, El Ahmadi, Delph, Westwood, Herd, Sylla, Tonev, Kozak, Helenius, Weimann, Agbonlahor, Bowery.