Manchester United manager David Moyes will assess the fitness of his international stars before settling on his line-up for Saturday's Old Trafford encounter with Southampton.
Robin van Persie and Wayne Rooney look certain to start in attack after both scored during the international break but Tom Cleverley is likely to miss out after picking up a calf injury prior to England's victory over Montenegro.
Moyes' major decision appears to revolve around 18-year-old Adnan Januzaj, who netted a match-winning brace on his full Premier League debut at Sunderland a fortnight ago.
Artur Boruc and Luke Shaw are both in contention for Southampton's trip to Manchester United on Saturday.
Saints boss Mauricio Pochettino expects Boruc to start again in goal, despite the Poland team physio claiming he suffered a hamstring injury during the international break.
Shaw was unable to link up with the England Under-21s due to illness but is also in contention, while Gaston Ramirez will be assessed after arriving back from international duty with Uruguay late on Thursday.
Man United: De Gea, Lindegaard, Amos, Rafael, Smalling, Jones, Ferdinand, Vidic, Evans, Evra, Fabio, Valencia, Nani, Fellaini, Carrick, Giggs, Anderson, Young, Zaha, Januzaj, Kagawa, Rooney, Van Persie, Welbeck, Hernandez.
Southampton: Boruc, K Davis, Gazzaniga, Clyne, Chambers, Shaw, Fox, Lovren, Hooiveld, Yoshida, Fonte, Schneiderlin, Cork, S Davis, Ward-Prowse, Wanyama, Lallana, Rodriguez, Ramirez, Do Prado, Osvaldo, Lambert, Lee.