Argentina internationals Fabricio Coloccini and Jonas Gutierrez will miss Saturday's Premier League clash with Liverpool.
Central defender Coloccini has been ruled out with a groin injury, while midfielder Gutierrez has been allowed to return to his native country for personal reasons.
Steven Taylor, a potential replacement for Coloccini, is unlikely to have recovered in time from a hamstring problem, so Mapou Yanga-Mbiwa is in line to start alongside Mike Williamson.
Defenders Glen Johnson and Aly Cissokho return to Liverpool's squad after lengthy injury lay-offs to face Newcastle.
Wales international Joe Allen is also back after a hamstring problem while fellow midfielder Lucas Leiva is included after serving a one-match suspension last time out.
Only Philippe Coutinho (shoulder) prevents manager Brendan Rodgers selecting from a fully-fit squad.
Newcastle: Krul, Elliot, Debuchy, Yanga-Mbiwa, Williamson, Good, Santon, Dummett, Tiote, Anita, Cabaye, Marveaux, Sissoko, Ben Arfa, Sammy Ameobi, Bigirimana, Vuckic, Cisse, Remy, Gouffran, Shola Ameobi.
Liverpool: Mignolet, Johnson, Toure, Skrtel, Sakho, Enrique, Lucas, Gerrard, Henderson, Suarez, Sturridge, Jones, Kelly, Agger, Wisdom, Ilori, Sterling, Allen, Moses, Alberto, Ibe, Aspas.