Manchester United striker Danny Welbeck has been ruled out of Sunday's Premier League showdown with Arsenal at Old Trafford.
Welbeck has been missing with a knee injury since the middle of October and manager David Moyes has confirmed the 22-year-old will not recover in time to face the leaders.
Jonny Evans may return after a back problem, whilst Robin van Persie will almost certainly face his old club despite missing a penalty following his introduction as a substitute into the midweek Champions League draw with Real Sociedad.
Provisional squad: De Gea, Lindegaard, Amos, Rafael, Smalling, Jones, Ferdinand, Vidic, Evans, Evra, Fabio, Valencia, Nani, Fellaini, Carrick, Cleverley, Giggs, Anderson, Young, Zaha, Januzaj, Kagawa, Rooney, Van Persie, Hernandez.
Arsenal will check on the fitness of England midfielder Jack Wilshere (ankle) ahead of Sunday's Barclays Premier League trip to Manchester United.
Midfielder Mathieu Flamini is set to return to full training following his groin injury and so could feature at Old Trafford.
Theo Walcott (abdominal surgery), Yaya Sanogo (back), Lukas Podolski (hamstring), Alex Oxlade-Chamberlain and Abou Diaby (both knee) remain sidelined.
Provisional squad: Szczesny, Sagna, Mertesacker, Koscielny, Gibbs, Cazorla, Ozil, Ramsey, Rosicky, Arteta, Giroud, Fabianski, Gnabry, Jenkinson, Vermaelen, Bendtner, Monreal, Wilshere, Flamini.