Premier League leaders Arsenal will have forward Theo Walcott back from two months out following abdominal surgery for the visit of Southampton.
German defender Per Mertesacker, who scored at Wembley on Tuesday night, has recovered from a virus which ruled him out of the defeat at Manchester United, but midfielder Mathieu Flamini is suspended.
England midfielder Jack Wilshere has returned from international duty with no fresh fitness concerns. Yaya Sanogo (back), Lukas Podolski (hamstring), Alex Oxlade-Chamberlain and Abou Diaby (both knee) all remain sidelined.
Jack Cork will miss Southampton's trip to league leaders Arsenal due to an ankle injury.
The 24-year-old midfielder has been unable to train properly for a week after badly twisting his ankle and will miss the trip to the Emirates Stadium, although it is unclear how much longer he faces out.
Guly do Prado is also absent after undergoing a knee operation, while Gaston Ramirez's fitness will be checked after arriving back from international duty with Uruguay on Friday lunchtime.
Arsenal Squad: Szczesny, Sagna, Mertesacker, Koscielny, Gibbs, Arteta, Wilshere, Cazorla, Ramsey, Ozil, Giroud, Fabianski, Walcott, Bendtner, Gnabry, Rosicky, Jenkinson, Monreal, Vermaelen.
Southampton squad: Boruc, K Davis, Clyne, Chambers, Shaw, Fox, Lovren, Fonte, Yoshida, Hooiveld, Ward-Prowse, Schneiderlin, Wanyama, S Davis, Lallana, Ramirez, Lee, Gallagher, Lambert, Rodriguez, Osvaldo.