Andreas Cornelius returns from an ankle injury for Cardiff, while David Moyes has a decision to make over Nemanja Vidic.
The Dane has been sidelined for 10 weeks since suffering the injury in the Capital One Cup tie against Accrington, but he featured for the Under-21s last week and is available to face the league champions.
Peter Odemwingie has been passed fit after returning from international duty with Nigeria, with Aron Gunnarsson is also in the squad after Iceland's World Cup play-off defeat to Croatia.
Manchester United manager David Moyes must decide whether Nemanja Vidic will be fit enough to skipper his team at Cardiff on Sunday.
Vidic needed hospital treatment after suffering concussion against Arsenal immediately prior to the international break, but has now returned to training.
Michael Carrick (Achilles) and Phil Jones (groin) are definitely out, while Robin van Persie missed the Holland's recent matches with a long-standing toe problem and Marouane Fellaini has a wrist complaint that will eventually require surgery.
Cardiff squad: Marshall, Connolly, Taylor, Caulker, Hudson, Turner, Whittingham, Cowie, Medel, Cornelius, Campbell, Brayford, Kim, Smith, Gestede, Noone, Gunnarsson, Mutch, Odemwingie, Mason, Maynard, Lewis, Moore, Bellamy, Theophile-Catherine.
Man United squad: De Gea, Lindegaard, Amos, Rafael, Smalling, Ferdinand, Vidic, Evans, Evra, Fabio, Valencia, Nani, Fellaini, Cleverley, Giggs, Anderson, Young, Zaha, Januzaj, Kagawa, Rooney, Van Persie, Hernandez, Welbeck.