Man United winger Nani will miss Saturday's Premier League encounter with West Ham at Old Trafford.
The Portugal international has been ruled out with a hamstring injury and joins Robin van Persie (thigh) and Michael Carrick (Achilles) on the sidelines.
Wayne Rooney could be available after a groin injury as United look to avoid a third successive league defeat on home soil for the first time since 1979.
West Ham manager Sam Allardyce will welcome back James Tomkins for the Barclays Premier League game at Manchester United.
The defender missed the midweek Capital One Cup win over Tottenham with a groin injury but is now back in contention.
Captain Kevin Nolan again misses out as he serves the last of his three-match ban for his sending off at Liverpool while
Winston Reid (ankle), Stewart Downing (calf), Andy Carroll (heel), Ricardo Vaz Te (shoulder) and Mladen Petric (thigh) are also absent.
Man United squad: De Gea, Lindegaard, Johnstone, Rafael, Smalling, Ferdinand, Evans, Evra, Vidic, Fabio, Valencia, Nani, Jones, Fletcher, Cleverley, Giggs, Anderson, Young, Zaha, Januzaj, Rooney, Welbeck, Kagawa, Hernandez.
West Ham Squad: Jaaskelainen, Demel, Tomkins, McCartney, Collins, Noble, Jarvis, J Cole, Diame, Morrison, Maiga, Adrian, Collison, O'Brien, Rat, Taylor, Diarra, C Cole