Hull expect to be without goalkeeper Allan McGregor and midfielder David Meyler, while Fulham are missing first-choice goalkeeper Maarten Stekelenbur.
Both players came off at half-time with knee problems in the 3-2 Boxing Day loss to Manchester United and are unlikely to manage the quick turnaround.
Alex Bruce is also struggling with a calf complaint sustained in the same match, while Stephen Quinn (hamstring) and Sone Aluko (Achilles) remain sidelined.
Fulham will also be without their first-choice goalkeeper, Maarten Stekelenburg.
David Stockdale deputised in the 2-1 win at Norwich after Stekelenburg injured an ankle in training on Christmas Day and the Holland international remains sidelined.
Dimitar Berbatov (groin) also missed the trip to Carrow Road but could feature at Hull whilst Brede Hangeland (back), Philippe Senderos (abductor) and Matthew Briggs (hernia) are out.
Hull squad: Harper, Jakupovic, Davies, Chester, Faye, Figueroa, Bruce, Rosenior, Elmohamady, Brady, Livermore, Huddlestone, Koren, Sagbo, McShane, Graham, Fryatt, Gedo.
Fulham Squad: Stockdale, Riether, Hughes, Riise, Sidwell, Parker, Karagounis, Dejagah, Berbatov, Kacaniklic, Kasami, Ruiz, Bent, Bettinelli, Richardson, Duff, Zverotic, Vigen Christensen, Amorebieta.