Andros Townsend is in line to make his first Spurs appearance for seven weeks, while Seamus Coleman could feature for Everton.
The England winger suffered a hamstring injury against West Ham on December 15 and will return to the squad to face the Toffees.
Mousa Dembele is available after missing last weekend's trip to Hull with a thigh problem, although Erik Lamela, Vlad Chiriches and Sandro are sidelined for the clash.
Forwards Gerard Deulofeu and Lacina Traore are both set for inclusion in Everton's squad to face Tottenham at White Hart Lane on Sunday.
Deulofeu has been sidelined since mid-December with a hamstring strain while a similar complaint has meant on-loan Traore has yet to be involved following his January loan move from Monaco.
Defender Seamus Coleman is set to return to the starting line-up after being an unused substitute last weekend following recovery from injury but centre-back Antolin Alcaraz is not quite ready to come back from muscle fatigue.
Spurs squad: Lloris, Friedel, Archer, Gomes, Walker, Naughton, Dawson, Vertonghen, Kaboul, Rose, Fryers, Dembele, Capoue, Eriksen, Bentaleb, Paulinho, Chadli, Townsend, Sigurdsson, Lennon, Soldado, Adebayor, Kane, Defoe.
Everton squad: Howard, Coleman, Jagielka, Distin, Baines, Barry, McCarthy, McGeady, Barkley, Osman, Mirallas, Robles, Stones, Hibbert, Pienaar, Naismith, Deulofeu, Traore, Vellios.