The most eagerly anticipated Champions League tie of the knockout stages is live on ITV and ITV.com/football.
Join Adrian Chiles, Roy Keane, Lee Dixon and Roberto Martinez in the studio tonight from 7:30pm for build-up to this round's most eye-catching match up, with kick-off at 7:45pm.
Manuel Pellegrini's side are still chasing an unprecedented quadruple, and will be hoping to send out a strong message to the rest of Europe by beating one of the tournament's strongest teams.
Jose Mourinho may believe this Barcelona is the worst for many years but the Catalan giants are joint top of La Liga, fresh from a 6-0 demolition of Rayo Vallecano, and boast global superstars Lionel Messi and Neymar.
It's the game everyone has been waiting for, so don't forget to tune in and let us know your predictions before the match @ITVFootball.