Find out if Spurs can overturn a one goal deficit from the Ukraine when they welcome Dnipro to White Hart Lane, live on ITV and ITV.com/football.
Tim Sherwood's side failed to score a precious away goal despite having a glorious second-half chance wasted by misfiring striker Roberto Soldado.
The competition represents Sherwood's only chance of winning silverware this season, with a potential knockout tie against Portuguese giants Benfica to follow if they manage to get past this tricky round.
Join our team in the studio on ITV from 7:45pm on Thursday 27th February, for 15 minutes of build-up to the match which kicks-off at 8pm.
Watch highlights of Dnipro 1-0 Spurs below