Watch Porto v Napoli in the Europa League last 16, live on ITV4 and ITV.com/football from 5:45pm.
The Portuguese side staged a remarkable comeback at Frankfurt in the last round, scoring three times in the second-half to progress on away goals.
Manager Paulo Fonseca has since been fired, the nine point gap to Portuguese league leaders Benfica simply unacceptable for ruthless chairman Pinto Da Costa.
Luis Castro has been promoted as interim boss and, following Sunday's 4-1 league win against Arouca, is tasked with gaining a first leg advantage over Rafael Benitez's Napoli.
Brimming with confidence after beating Roma at the weekend, will the Italians come away from Portugal with a positive result? We're expecting a thriller.