Tottenham will be without captain Michael Dawson for the north London derby with Arsenal, while Kyle Walker is a major doubt.
A hamstring injury suffered in last weekend's 4-0 defeat at Chelsea will keep centre-back Dawson out of Sunday's match, while a pelvic complaint may well sideline right-back Walker.
Danny Rose (knee) could return to the starting line-up having featured from the bench in Thursday's Europa League loss to Benfica, while Tim Sherwood will be hoping Mousa Dembele is also in contention. Etienne Capoue (ankle), Erik Lamela and Vlad Chiriches (both back) all remain sidelined.
Arsenal will be without midfielder Mesut Ozil for at least three weeks because of a hamstring tear as the Gunners prepare for Sunday's north London derby at Tottenham.
Goalkeeper Wojciech Szczesny will return from a midweek European suspension while full-back Nacho Monreal and striker Yaya Sanogo have recovered from foot injuries
Midfielder Kim Kallstrom (back) could be in the squad for the first time. However, defender Kieran Gibbs (calf) remains a doubt, midfielder Aaron Ramsey (thigh) is still a couple of weeks away from full fitness, while Jack Wilshere (foot), Theo Walcott and Abou Diaby (both knee) remain out.
Spurs: Lloris, Friedel, Walker, Naughton, Kaboul, Vertonghen, Rose, Fryers, Sandro, Dembele, Bentaleb, Paulinho, Lennon, Eriksen, Chadli, Townsend, Sigurdsson, Adebayor, Soldado, Kane.
Arsenal: Szczesny, Vermaelen, Mertesacker, Koscielny, Sagna, Arteta, Flamini, Cazorla, Oxlade-Chamberlain, Rosicky, Giroud, Fabianski, Podolski, Gnabry, Monreal, Sanogo, Kallstrom, Jenkinson, Gibbs.