Saints have a lengthy injury list heading into Saturday's Barclays Premier League clash with Newcastle.
Jay Rodriguez (knee), Morgan Schneiderlin (hip muscles), Victor Wanyama (leg) and Steven Davis (groin) are all doubts for the encounter at St Mary's.
Nathaniel Clyne (groin), Kelvin Davis (hip) and Maya Yoshida (knee) are definitely absent, with the latter facing six weeks out.
Keeper Tim Krul is out of Newcastle's trip to Southampton and facing several weeks on the sidelines.
The Holland international suffered a knee injury in Tuesday night's 3-0 home defeat by Everton and will sit out up to three games with Rob Elliot taking his place.
Full-back Davide Santon could return after recovering from tonsillitis, but full-back Mathieu Debuchy (groin), midfielder Sammy Ameobi (ankle) and striker Loic Remy (calf), remain on the sidelines, although leading scorer Remy is due to resume full training on Monday.
Southampton: Boruc, Gazzaniga, Cropper, Chambers, Shaw, Targett, Lovren, Fonte, Hooiveld, Reed, Ward-Prowse, Cork, Schneiderlin, S Davis, Wanyama, Rodriguez, Ramirez, Do Prado, Lallana, Gallagher, Lambert.
Neqcastle: Elliot, Alnwick, Santon, Dummett, Haidara, Coloccini, Williamson, Yanga-Mbiwa, S. Taylor, Tiote, Anita, Marveaux, Sissoko, Ben Arfa, Gouffran, Gosling, Cisse, De Jong, Shola Ameobi, Armstrong.