Morgan Schneiderlin has joined Southampton's injury list heading into Saturday's Premier League clash with Everton.
The French midfielder received a heavy knock to his quadriceps and joins Jay Rodriguez (knee) and Gaston Ramirez (ankle) on the sidelines.
Maya Yoshida (knee) remains absent for Saints for the Toffees' visit, as does back-up goalkeeper Kelvin Davis (back).
Defender Sylvain Distin misses Everton's trip to Southampton with a hamstring injury.
With fellow centre-back Phil Jagielka still a week away from returning from a similar problem it means John Stones and Antolin Alcaraz will be central defensive partners.
Forward Kevin Mirallas (groin) has been ruled out for the remainder of the season and with Darron Gibson, Aroune Kone, Bryan Oveido, Steven Pienaar and Lacina Traore all still sidelined manager Roberto Martinez will look to his under-21s to bolster his squad.
Southampton squad: Boruc, Gazzaniga, Cropper, Clyne, Chambers, Shaw, Targett, Hooiveld, Fonte, Lovren, Cork, Wanyama, S Davis, Ward-Prowse, Do Prado, Reed, Lallana, Lambert, Gallagher.
Everton squad: Howard, Coleman, Stones, Alcaraz, Baines, Barry, McCarthy, Deulofeu, Barkley, Osman, Lukaku, Robles, Hibbert, Garbutt, Browning, McGeady, Naismith, Gueye.