Tottenham will be looking to replicate local rivals Arsenal's recent success against Besiktas after being paired with the Turkish side in Group C of the Europa League.
The Gunners edged past Besiktas over two legs in the Champions Leagiue play-offs, with Slaven Bilic's side dropping down to become top seeds in the secondary competition where they face a return to North London.
Also on the agenda for Mauricio Pochettino's side are trips to Serbia's Partizan Belgrade and Greek side Asteras.
Everton, coming from pot three at the draw in Monaco, have a tough draw in Group H, where they play a Lille side spearheaded by on-loan Liverpool striker Divock Origi and Bundesliga outfit Wolfsburg as well as a tricky journey to Russia's Krasnodar.
Scottish champions Celtic avoided meeting Legia Warsaw, the side who they controversially beat in Champions League qualifying due to a technicality, and take the second seed in Group D alongside Salzburg, Dinamo Zagreb and Astra Giurgiu.
The first round of fixtures will take place on September 18th 2014.
GROUP A: Villarreal, Monchengladbach, Zurich, Apollon
GROUP B: Copenhagen, Club Brugge, Torino, HJK
GROUP C: Spurs, Besiktas, Partizan, Asteras
GROUP D: Salzburg, Celtic, Dinamo Zagreb, Astra
GROUP E: PSV, Panathinaikos, Estoril, Dinamo Moscow
GROUP F: Inter Milan, Dnipro, St-Etienne, Qarabag
GROUP G: Sevilla, Standard Liege, Feyenoord, Rijeka
GROUP H: Lille, Wolfsburg, Everton, Krasnodar
GROUP I: Napoli, Sparta Prague, Young Boys, Slovan Bratislava
GROUP J: Dynamo Kiev, Steaua, Rio Ave, AaB
GROUP K: Fiorentina, PAOK, Guingamp. Dinamo Minsk
GROUP L: Metalist, Trabzonspur, Legia, Lokeren