Sean Dyche expects striker Sam Vokes to once again be Burnley's only absentee when Manchester United visit Turf Moor.
Wales international Vokes has a long-term knee problem but was back doing some running on the grass at the Clarets' training ground this week.
Dyche will likely recall a number of players who were rested in the Capital One Cup defeat to Sheffield Wednesday in midweek, including goalkeeper Tom Heaton, long-serving defender Michael Duff and striker Danny Ings.
British record signing Angel Di Maria is fit to make his Manchester United debut.
Midfielders Michael Carrick, Marouane Fellaini and Ander Herrera (all ankle) are out, as is utility man Jesse Lingard, who has a knee injury.
Defenders Luke Shaw (hamstring), Chris Smalling (groin) and Marcos Rojo (awaiting work permit) are unavailable, while doubts remain over right-back Rafael (groin) and midfielder Shinji Kagawa, who suffered concussion in Tuesday's defeat at MK Dons.
Burnley squad: Heaton, Trippier, Ward, Duff, Shackell, Mee, Wallace, Marney, Ings, Kightly, Jones, Taylor, Sordell, Reid, Jutkiewicz, Gilks, Long, Barnes, Hewitt, Arfield.
Man United squad: De Gea, Lindegaard, Amos, Rafael, Valencia, Evans, Jones, M Keane, Blackett, James, Fletcher, Cleverley, Anderson, Young, Mata, Di Maria, Kagawa, Januzaj, Van Persie, Rooney, Welbeck, Hernandez, Powell, W Keane.