Oxford face Barrow for the second time in a week with a place in the third round of the FA Cup at stake.
United ran out 1-0 winners when the sides met in the league a week ago, courtesy of James Constable's 14th goal of the season from the penalty spot.
Manager Chris Wilder will be without loan duo Matt Green and Onome Sodje for the clash, though, with their respective parent clubs refusing them permission to play.
Defender Damien Batt is struggling with a knock picked up against Forest Green in midweek and could be replaced by Adam Chapman, while Jamie Cook, Adam Murray and winger Alfie Potter are pushing for a return to the starting line-up.
Barrow have been boosted by the arrival of three loan signings ahead of the encounter.
Striker Gregg Blundell and midfield duo Marc Goodfellow and Gavin Rothery have joined from Chester, Burton and Carlisle respectively to bolster the Cumbrians' squad.
All three are expected to come into contention this weekend but on-loan Rochdale striker Jon Shaw has been recalled by his parent club.
Shaw - who has a calf injury - spent the maximum three months on loan at Holker Street and is expected to be farmed out to another club until January.
Fellow forward Jason Walker is expected to overcome a hamstring injury sustained in midweek against Grays but on-loan York midfielder Craig Nelthorpe is ineligible.
