Tom Heaton and Ashley Barnes were the heroes as Burnley picked up their third win of the season against stuttering Saints
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Matt Targett, the latest left-back off Southampton's production line, has penned a five-year deal with his boyhood club.
The 19-year-old has impressed since breaking into the first team this season, with his debut coming in August's Capital One Cup defeat of Millwall.
Targett has been rewarded with a new deal until 2019 at a club which has seen Gareth Bale, Wayne Bridge and Luke Shaw flourish after being given a chance at left-back.
Southampton manager Ronald Koeman expects Jay Rodriguez's rehabilitation from a long-term knee injury to keep him out for at least another six weeks.
An awkward fall at Manchester City in April saw the 25-year-old rupture an anterior cruciate ligament, the injury ruling him out of the reckoning for England's World Cup squad.
Rodriguez has yet to make his return more than eight months later and, having gone under the knife again last month to clear out his knee, a comeback does not appear imminent.
Jack Cork faces at least six weeks on the sidelines as Southampton's injury problems mount ahead of Monday's Premier League clash with Manchester United.
Saints manager Ronald Koeman revealed the midfielder sustained ankle ligament damage in Wednesday's defeat at Arsenal, when Toby Alderweireld was forced off with a hamstring complaint which makes him a doubt.
Morgan Schneiderlin is unavailable, as are long-term absentees Jay Rodriguez (knee), James Ward-Prowse (foot) and Sam Gallagher (knee), but Dusan Tadic has overcome a knock.
Southampton provisional squad: Forster, K Davis, Cropper, Clyne, Alderweireld, Fonte, Yoshida, Gardos, Bertrand, Targett, Wanyama, Reed, Hesketh, S Davis, Isgrove, Mane, Tadic, Long, Mayuka, Pelle.