Chelsea striker Diego Costa has withdrawn from the Spain squad for their European Championship qualifier with Macedonia
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Andres Iniesta has been ruled out of Spain's upcoming matches against France and Macedonia through injury.
The midfielder is struggling with a knee problem that forced him to miss Barcelona's match with Villarreal at the weekend and he will not be available to national team coach Vicente del Bosque.
Real Madrid midfielder Xabi Alonso has announced his retirement from international football.
The 32-year-old was a member of the Spain squads which won the World Cup in 2010 and European Championships in 2008 and 2012 during a sustained period of dominance - but that run came to an end with a miserable World Cup in Brazil this summer as they were dumped out before the group stages had even concluded.
I announce my retirement from international football. It's been an enormous honour for 11 great years. Sincere thanks to everyone involved.
Adidas image of Spain's black & yellow second strip for World Cup, which'll be worn in friendly v Italy on March 5 http://t.co/q6s2U1qq8U